Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)

The ARPA‑H solicitation ARPA‑H‑SOL‑26‑139 requires proposers to submit a comprehensive technical and cost proposal that identifies the primary organization (prime contractor) and any sub‑awardees or consultants, the specific place(s) of performance (e.g., commercial laboratory, nonprofit site, academic campus), and all deliverables (data, reports, software, etc.) to be provided to the Government. The proposal must enumerate every task and subtask, align them with the Phase‑specific spreadsheets in the Cost Workbook, and include measurable milestones (demonstrations, events, or other progress markers). Required sections cover organizational conflict‑of‑interest, research security, novelty of the work, intellectual‑property strategy (including freedom‑to‑operate analysis and licensing plans), and disclosures for human‑ and/or animal‑subjects research. Cost submissions must include a fully disclosed sub‑proposer spreadsheet, a prime‑level cost/price analysis, and justification for any non‑competitive or sole‑source sub‑awards. The effort is organized into up to six phases, each with estimated total costs and resource‑share percentages, and must meet a minimum 120‑day proposal validity period. Proposers must indicate the type of submission (Type A technical areas or Type B acceleration platform), provide a clear technical plan (preparation, research, development), and demonstrate high‑risk/high‑reward potential, commercialization pathways, and alignment with ARPA‑H’s mission to transform biomedicine. All required forms, cover sheets, and tables of contents must be completed, and misrepresentations are subject to federal penalties.

Notice ID

0993e235f83347b386772f7008e38043

Solicitation Number

ARPA-H-SOL-26-139

NAICS Code

541715

Classification Code

AN13