Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO)

The Advanced Research Projects Agency for Health (ARPA‑H) Health Science Futures Mission Office is issuing Innovative Solutions Opening (ISO) ARPA‑H‑SOL‑24‑104 (Amendment 03) to solicit solution summaries and full proposals for novel, high‑impact biomedical and health research that cannot be achieved through traditional programs. Eligible proposers—academia, non‑profit, and for‑profit entities—must submit via the ARPA‑H Solution Submission Portal by the open‑ended deadline of 5 March 2029. Proposals must include a detailed task list organized by Phase (with task titles, sub‑tasks, location, responsible organization, IP assertions, human/animal subject considerations, and associated milestones), a complete cost/price analysis, and Excel cost spreadsheets for any sub‑proposers. Competition for sub‑awards must be documented; if a sole‑source award is pursued, a concise justification is required. Submissions must be conforming (containing all required information, fitting the ISO interest areas, and meeting eligibility and submission criteria) and cannot be duplicated across multiple ARPA‑H ISOs. ARPA‑H will evaluate each proposal on its own merit using four criteria—scientific/technical merit, relevance to the ARPA‑H mission, proposer capabilities/experience, and cost/price assessment—without ranking proposals against one another. Additional requirements include certification that no team member participates in a malign foreign talent recruitment program and adherence to applicable legal statutes on misrepresentation. Awards will be made under Other Transaction (OT) instruments, with multiple awards anticipated and potential resource‑sharing encouraged.

Notice ID

17c41c5232d5458da16970f553ecd31c

Solicitation Number

ARPA-H-SOL-24-104

NAICS Code

541715

Classification Code

AN13