Antibacterial Nanoparticles Therapeutic (ANT) Study

The Walter Reed Army Institute of Research Bacterial Diseases Branch (WRAIR‑BDB), under the Defense Health Agency, is issuing a Sources‑Sought RFI (PANDHA‑26‑P‑0000_036893) to identify qualified contractors to conduct a non‑personnel research and development study of phage‑mimicking antibacterial nanoparticles (PhANPs) against combat‑relevant, multi‑drug‑resistant (MDR) Pseudomonas aeruginosa. In partnership with the University of Notre Dame (patent US‑12161725‑B2), the effort will produce and characterize 17 batches of silver‑gold nanoparticles conjugated to an antimicrobial peptide/polymer (≈500 mL of 200 µM stock per batch), test their activity against MDR P. aeruginosa biofilms in wound‑like media, and generate the data needed to support future FDA approval. The contractor must supply qualified research personnel, appropriate laboratory facilities, equipment, and all required materials; complete three sequential milestones (production and lyophilization of PhANPs, in‑vitro efficacy testing, and delivery of QC certificates and comprehensive property data—including purity, composition, residual reagents, particle size/distribution, morphology via TEM/SEM, and stability/suspension characteristics); and bear all packaging and shipping costs to the WRAIR facility in Silver Spring, MD. Responses are limited to a three‑page electronic submission (Microsoft Word 2000/2007 or PDF) in 12‑point font, including a one‑page cover sheet with contact information and NAICS 541713 code. Submissions must be emailed to Ms. Linda Hinson (linda.t.hinson.civ@health.mil) and Mr. Sharew Haily (sharew.hailu.civ@health.mil) no later than 10:00 a.m. ET on 1 April 2026. No hard copies, phone calls, or future‑acquisition inquiries will be accepted; all information provided will be treated as confidential business information.

Notice ID

2dc9538915e14664b602b2539c48d0ed

Solicitation Number

PANDHA-26-P-0000_036893

NAICS Code

541713

Classification Code

AN13