Resilient Systems Office (RSO) Mission Office Innovative Solutions Opening (ISO)

The Advanced Research Projects Agency for Health (ARPA‑H) Resilient Systems Office is issuing Innovative Solutions Opening (ISO) ARPA‑H‑SOL‑24‑103 (Amendment 03, 14 Oct 2025) to acquire novel, high‑impact biomedical and health‑system solutions that cannot be pursued through traditional research or commercial pathways. The solicitation remains open through 5 Mar 2029 and will award multiple Other‑Transaction (OT) agreements to eligible academia, non‑profit, and for‑profit entities. Proposers must submit a Solution Summary and, if selected, a full proposal via the ARPA‑H Solution Submission Portal, addressing the defined task phases, technical approach, anticipated health‑system impact, and risk mitigation. Evaluation will be based on scientific/technical merit, relevance to ARPA‑H’s mission, proposer capability, and cost/price assessment. All sub‑proposals must be accompanied by Excel cost spreadsheets; the prime must conduct a cost/price analysis, demonstrate competition to the maximum practicable extent, and provide sole‑source justifications where applicable. Sub‑award terms (e.g., fixed‑price, cost‑plus‑fixed‑fee, T&M) and intellectual‑property assertions must be identified. Offerors must certify compliance with foreign‑talent recruitment prohibitions and acknowledge potential liability for misrepresentations. Resource sharing may be encouraged, and the solicitation includes detailed milestones, deliverables, and required certifications regarding human/animal subjects research.

Notice ID

afb42f0cb40041baa180f7413ba2f7b1

Solicitation Number

ARPA-H-SOL-24-103

NAICS Code

541715

Classification Code

AN13